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Management of adults with hypocalcemia after thyroid surgery

Management of adults with hypocalcemia after thyroid surgery
Postoperative day Serum tests Therapy
Night of surgery Calcium in the evening (approximately 8 PM) Ca <7.5 mg/dL: Calcitriol 0.5 mcg three times daily x three days and calcium gluconate 3 g/L D5 1/2 normal saline IV at 100 mL/hour
Day 1 Calcium and phosphorus in the morning (approximately 6 AM); if Ca <7.5 mg/dL, add magnesium

Ca <7.5 mg/dL: Calcitriol 0.5 mcg twice daily x three days and adjust depending upon calcium response and calcium gluconate 3 g/L D5 1/2 normal saline IV at 100 mL/hour and calcium carbonate (1 to 4 g elemental calcium) by mouth daily in divided doses depending upon calcium response

Ca 7.5 to 8.0 mg/dL: Calcitriol 0.5 mcg twice daily x three days and adjust depending upon calcium response and calcium carbonate (1 to 4 g elemental calcium) by mouth daily in divided doses depending upon calcium response

Ca >8.0 mg/dL: Calcium carbonate (1 g elemental calcium) by mouth twice daily

Mg <2 mg/dL: Magnesium sulfate 4 g in 100 mL normal saline IV at 33 mL/hour and magnesium oxide 400 mg by mouth twice daily x one month
Day 2 to 4 If day 1 Ca ≤8.0 mg/dL, total calcium and phosphorus

Ca <7.5 mg/dL and symptomatic: Calcitriol 0.25 mcg three times daily and calcium gluconate 3 g/L D5 1/2 normal saline IV at 100 mL/hour and calcium carbonate (1 to 4 g elemental calcium) by mouth daily in divided doses and modify based upon calcium response

Ca <7.5 mg/dL and asymptomatic: Calcitriol 0.25 mcg three times daily and calcium carbonate (1 to 4 g elemental calcium) by mouth daily in divided doses and modify based upon calcium response

Ca 7.5 to 8.4 mg/dL or P ≥4.5 mg/dL: Calcitriol 0.25 mcg daily and calcium carbonate (1 to 4 g elemental calcium) by mouth daily in divided doses and modify based upon calcium response

Ca 8.5 to 9.4 mg/dL and P ≤4.5 mg/dL: Calcium carbonate (1 to 4 g elemental calcium) by mouth daily in divided doses and modify based upon calcium response

Ca ≥9.5 mg/dL: No therapy
To convert serum calcium to mmol/L, divide by 4. To convert serum phosphorus to mmol/L, divide by 3.1.
Ca: calcium; IV: intravenous; Mg: magnesium; P: phosphorus.
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