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Differential diagnosis of unknown primary cancers based upon immunostaining for cytokeratin (CK) 7 and 20

Differential diagnosis of unknown primary cancers based upon immunostaining for cytokeratin (CK) 7 and 20
CK7+ CK20+
Urothelial tumors
Mucinous ovarian cancer
Pancreatic or biliary cancer
CK7+ CK20-
Non-small cell lung cancer
Small cell lung cancer
Breast cancer
Endometrial cancer
Nonmucinous ovarian cancer
Mesothelioma
Squamous cancer of cervix
Pancreatic or biliary cancer
CK7- CK20+
Colorectal cancer
Merkel cell cancer
CK7- CK20-
Hepatocellular cancer
Renal cell cancer
Prostate cancer
Squamous cell lung cancer
Head and neck cancer
CK: cytokeratin; +: positive; -: negative.
Modified from: Dabbs D. Diagnostic Immunohistochemistry, 2nd ed, Churchill Livingstone, Philadelphia, PA 2006.
Graphic 58475 Version 4.0