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Reported cases of uterine rupture with misoprostol induction for pregnancy termination

Reported cases of uterine rupture with misoprostol induction for pregnancy termination
Lead author (publication date) Gestational age, weeks Previous uterine scar Gravidity Misoprostol dose (mcg)
Ruptures of previously scarred uteri
Jwarah (2007) 8 Yes G3 800 miso PV
Can (2020) 11 Yes G3 400 miso PV
Mazouni (2006) 16 Yes ? 600 mg mife followed 36 hours later by 200 miso PV every 3 hours up to 3 doses; miso doses repeated 24 hours later as needed
Daskalaikis (2005) 23 Yes G2 400 miso PO plus 400 PV given at first, then 400 PV dose 8 hours later
Berghahn (2001) 23 Yes G2(?) 400 miso PV then 400 buccal 6 hours later
Chen (1999) 23 Yes G3 200 miso PV
Mazouni (2006) 24 Yes ? 600 mg mife followed 36 hours later by 200 miso PV every 3 hours up to 3 doses; miso doses repeated 24 hours later as needed
Nayki (2005) 26 Yes G2(?) 200 miso PV every 3 hours up to 4 doses
Ruptures involving major malformation of uterus
Samuels (2005) 18 No (pregnancy in noncommunicating rudimentary horn) G1 200 miso PV
Ruptures involving relatively high doses of misoprostol
Phillips (1996) 18 No G4 200 mg mife followed by 600 miso PV every 6 hours for 2 doses
Ruptures involving high cumulative doses of misoprostol
Bagga (2004) 20 No G4 200 mg mife followed by 200 miso PV every 6 hours for 6 doses
Letourneur (2002) 25 No G1 600 mg mife followed by 200 miso PO for 7 doses
Miso: misoprostol; Mife: mifepristone; PV: per vaginam; PO: per oral route; ?: indicates that the article is not fully clear on the given point.
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