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Disorders of extracellular calcium-sensing by the CaSR

Disorders of extracellular calcium-sensing by the CaSR
Disorders with generalized decrease in sensitivity to Ca2+ (affecting all CaSR-expressing tissue)
FHH
NHPT and NSHPT
Familial isolated hyperparathyroidism caused by CaSR mutations
Autoimmune hypocalciuric hypercalcemia
Disorders with parathyroid-specific decrease in sensitivity to Ca2+
Primary hyperparathyroidism
Severe uremic secondary and tertiary hyperparathyroidism
Disorders with generalized increase in sensitivity to Ca2+
ADH due to activating CaSR mutations
ADH with features of Bartter syndrome
Hypoparathyroidism due to activating antibodies to the CaSR
CaSR: calcium-sensing receptor; Ca: calcium; FHH: familial hypocalciuric hypercalcemia; NHPT: neonatal hyperparathyroidism; NSHPT: neonatal severe hyperparathyroidism; ADH: autosomal dominant hypoparathyroidism.
Graphic 58108 Version 4.0