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Uptodate Reference Title
T4 metabolism in nonthyroidal illness
T4 metabolism in nonthyroidal illness
The inhibition of 5'-monodeiodinase in nonthyroidal illness leads to decreased conversion of T4 to T3 and reduced metabolism of rT3. The induction of 5-monodeiodinase (D3) leads to increased conversion of T4 to rT3 and the metabolism of T3.
