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Uptodate Reference Title
Myeloma cast: Light microscopy
Myeloma cast: Light microscopy
High-power light micrograph shows PAS stain of tubular casts in myeloma kidney. The bottom two tubules contain casts composed of PAS-negative immunoglobulin light chains (small arrows). By comparison, the cast in the middle tubule (probably hyaline) is primarily composed of PAS-positive Tamm-Horsfall mucoprotein, the matrix of all casts (large arrow). Myeloma proteins are PAS negative because they contain few of the neutral sugars that are detected by this stain.