| Disorder | Target | IgE-mediated? | Symptoms |
| Immediate hypersensitivity | Systemic | Yes | Rapid onset of nausea, abdominal pain, vomiting, and/or diarrhea; often with hives and wheezing |
| Oral allergy syndrome | Oral | Yes | Mild tingling or angioedema of the lips or oropharynx; occasional sensation of tightness in the throat |
| Eosinophilic esophagitis | Esophagus | No; T cell-mediated | Gastroesophageal reflux, dysphagia, abdominal pain, or lack of histologic response to acid suppression; ± esophageal strictures |
| Eosinophilic gastroenteritis | Stomach, small bowel | No; T cell-mediated | Recurrent abdominal pain, intermittent vomiting, failure to thrive, or weight loss; ± ascites |
| Food protein-induced allergic proctocolitis | Rectum, sigmoid colon | No | Gross or occult blood in stool; otherwise, typically asymptomatic |
| Food protein-induced enteropathy | Small bowel | No | Diarrhea or steatorrhea, abdominal distension, failure to thrive, nausea, or vomiting |
| Food protein-induced enterocolitis syndrome (FPIES) | Small bowel, colon | No | Protracted vomiting and diarrhea (± blood), dehydration, shock, or failure to thrive |
