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Vaughan Williams classification of antiarrhythmic drugs

Class IA - slows conduction velocity (less than class IC) and prolongs APD

Disopyramide

Procainamide*

Quinidine

Class IB - has no effect on conduction velocity and may shorten APD

Lidocaine*

Mexiletine

Phenytoin

Class IC - slows conduction and may prolong APD (mild)

Flecainide

Propafenone

Class II - blocks beta adrenergic receptors

Beta blockers

Class III - prolongs APD and has no effect on conduction

Amiodarone

Dofetilide

Ibutilide*

Sotalol^¶

Dronedarone

Class IV - calcium channel blockers

Non-dihydropyridine calcium channel blockers (verapamil and dilitiazem)

APD: action potential duration.
* Available only as an intravenous preparation in United States. Oral procainamide is available elsewhere.
¶ l-sotalol has beta blocking and class III activities; d-sotalol is a pure class III agent. Commercially available sotalol is a racemic (equal part) mixture.

Vaughan Williams EM; Classifying antiarrhythmic actions: by facts or speculation; J Clin Pharmacol 1992; 32:964.

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