Histology of Grover's disease (transient and persistent acantholytic dermatosis)

Histopathology demonstrates acantholytic keratinocytes leading to suprabasilar clefting. Dyskeratotic keratinocytes extend from the mid-epidermis to the stratum corneum. Hemorrhage is noted in the intraepidermal cleft secondary to the mechanical trauma of repeated scratching (hematoxylin and eosin staining, original magnification 400x).