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SSRI and SNRI oral dosage (adult) for treatment of post-traumatic stress disorder (PTSD)

	Usual starting dose, mg	Low starting dose, mg	Therapeutic dose (daily), mg
Paroxetine	20	5 to 10	20 to 60
Sertraline	50	12.5 to 25	50 to 250
Fluvoxamine	50	25	100 to 300*
Fluoxetine	20	5 to 10	20 to 60
Citalopram	20	10	20 to 40^¶
Escitalopram	10	10	20 to 40
Venlafaxine (extended-release)	37.5	37.5	37.5 to 300

SSRI: selective serotonin reuptake inhibitor; SNRI: serotonin norepinephrine reuptake inhibitor.
* If an immediate release preparation of fluvoxamine is used, dose shown in table should be given in two divided doses.
¶ Maximum recommended dose of citalopram is 20 mg for patients >60 years of age, with significant hepatic insufficiency, or taking interacting medications that can increase citalopram levels. See UpToDate topic: "Unipolar depression in adults and selective serotonin reuptake inhibitors (SSRIs): Pharmacology, administration and side effects", sections "Citalopram" and "Cardiac". Specific interactions of citalopram with other medications may be determined using the drug interactions tool (Lexi-Interact Online) included in UpToDate. This tool can be accessed from the UpToDate online search page or through the individual drug information topics in the section on Drug interactions.

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