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Uptodate Reference Title
Splitting of the second heart sound
Splitting of the second heart sound
Wide splitting of second heart sound (S2) may be due to delayed closure of pulmonic valve as in right bundle branch block, pulmonic stenosis, and atrial septal defect, or to early closure of aortic valve as in mitral regurgitation and ventricular septal defect. In atrial septal defect, splitting is both wide and fixed.