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United States standardized extracts: Effective and ineffective doses and major allergen content

United States standardized extracts: Effective and ineffective doses and major allergen content
Allergen Effective doses* Ineffective doses* Labeling of United States standardized extracts Average major allergen content
Short ragweed 4 to 24 mcg Amb a 1 0.6 and 2 mcg Amb a 1 1:10 w/v (100,000 AU/mL) 520 mcg/mL Amb a 1
Dermatophagoides pteronyssinus 3.25 to 12 mcg Der p 1 0.7 mcg Der p 1 10,000 AU/mL 67 mcg/mL Der p 1
Dermatophagoides farinae 10 mcg Der f 1 Not determined 10,000 AU/mL 65 mcg/mL Der f 1
Timothy grass 15 and 20 mcg Phl p 5 2 mcg Phl p 5 100,000 BAU/mL 660 mcg/mL Phl p 5
Bermuda grass Not determined Not determined 10,000 BAU/mL 225 mcg/mL Cyn d 1
Cat hair or pelt 11 to 17 mcg Fel d 1 3 mcg Fel d 1 10,000 BAU/mL 40 mcg/mL Fel d 1
w/v: weight/volume; AU: allergy unit; BAU: bioequivalent allergy unit.
* Effective and ineffective doses are based upon double-blind, placebo-controlled studies.[1]
¶ Mean values. Individual lots of extracts may vary considerably from these values.[2]

References:

  1. Nelson HS. Subcutaneous injection immunotherapy for optimal effectiveness. Immunol Allergy Clin North Am 2011; 31:211.
  2. Plunkett G, ALK-Abello, Round Rock, Texas, personal communication. Values are based on analysis of dozens of extracts from all manufacturers in the US, 2011.
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