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Uptodate Reference Title
Benefit of leukotriene inhibitors in asthma
Benefit of leukotriene inhibitors in asthma
Effect of the leukotriene synthesis inhibitor zileuton (A) and the LTD4 receptor antagonist zafirlukast (B) on FEV1 in patients with mild to moderate asthma. Both drugs significantly improved the FEV1 compared with placebo.
Data from:
Israel E, Rubin P, Kemp JP, et al. The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma. Ann Intern Med 1993; 119:1059.
Spector SL, Smith LJ, Glass M, et al. Effects of 6 weeks of therapy with oral doses of ICI 204,219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma. ACCOLATE Asthma Trialists Group. Am J Respir Crit Care Med 1994; 150:618.
