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Uptodate Reference Title
Oxygen delivery (DO2) and consumption (VO2)
Oxygen delivery (DO2) and consumption (VO2)
In the normal state (blue line), oxygen consumption is constant over a range of DO2, and decreases only when DO2 falls below a critical level (critical DO2). Pathologic changes caused by sepsis or systemic inflammatory responses (red line) cause increased VO2 and impaired peripheral oxygen utilization, resulting in an elevation in critical DO2.