COX-2 selectivity* | Gastric IC50 (µM)¶ | |
NSAIDs | ||
Ketoprofen | 0.1 | 0.08 |
Ibuprofen | 0.6 | 0.70 |
Indomethacin | 0.7 | 0.85 |
Naproxen | 1.0 | 0.52 |
Piroxicam | 1.3 | 0.87 |
Ketoralac | 1.5 | 0.33 |
Nabumetone | 1.6 | 0.48 |
Etodolac | 7.9 | 3.20 |
Celecoxib | 9.2 | 11.14 |
Mefenamic acid | 12.1 | 0.70 |
Nimesulide (not available in US) | 58.3 | 1.49 |
Other analgesics | ||
Aspirin (acetylsalicylic acid) | 0.3 | 0.03 |
Salsalate (salicylsalicylic acid) | ≥2.8 | >100 |
Acetaminophen | 4.0 | >100 |