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Feminizing effects in male-to-female transgender persons

Feminizing effects in male-to-female transgender persons
Effect Onset Maximum
Redistribution of body fat 3 to 6 months 2 to 3 years
Decrease in muscle mass and strength 3 to 6 months 1 to 2 years
Softening of skin/decreased oiliness 3 to 6 months Unknown
Decreased sexual desire 1 to 3 months 3 to 6 months
Decreased spontaneous erections 1 to 3 months 3 to 6 months
Male sexual dysfunction Variable Variable
Breast growth 3 to 6 months 2 to 3 years
Decreased testicular volume 3 to 6 months 2 to 3 years
Decreased sperm production Unknown >3 years
Decreased terminal hair growth 6 to 12 months >3 years*
Scalp hair Variable —
Voice changes None —Δ
* Complete removal of male sexual hair requires electrolysis or laser treatment or both.
¶ Familial scalp hair loss may occur if estrogens are stopped.
Δ Treatment by speech pathologists for voice training is most effective.
Reproduced from: Hembree W, Cohen-Kettenis P, Gooren L. Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2017; 102(11):3869-3903. By permission of Oxford University Press on behalf of the Endocrine Society. Copyright © 2017 Oxford University Press. Available at: https://www.endocrine.org/guidelines-and-clinical-practice/clinical-practice-guidelines/gender-dysphoria-gender-incongruence.
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