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An approach to Japanese encephalitis vaccination

An approach to Japanese encephalitis vaccination
Preliminary considerations:
  • Health care providers should assess each traveler's risk for mosquito exposure and JE virus infection based on their planned itinerary and discuss ways to reduce their risk. All travelers to JE-endemic countries should be advised to take precautions to avoid mosquito bites to reduce the risk for JE and other vector-borne diseases. These precautions include using insect repellent, permethrin-impregnated clothing, and bed nets and staying in accommodations with screened or air-conditioned rooms.
  • For some individuals who might be at increased risk for JE based on travel duration, season, location, activities, and accommodations, JE vaccine can further reduce the risk for infection. The decision whether to vaccinate should be individualized and consider the risks related to the specific travel itinerary, the likelihood of future travel to JE-endemic countries, the high morbidity and mortality of JE, the availability of an effective vaccine, the possibility (but low probability) of serious adverse events after vaccination, and the traveler's personal perception and tolerance of risk.
 JE vaccine is recommended for:
  • Individuals moving to a JE-endemic country to take up residence
  • Longer-term travelers (eg, ≥1 month) to JE-endemic areas
  • Frequent travelers to JE-endemic areas
  • Laboratory workers with potential for exposure to JE viruses (other than SA14-14-2 JE vaccine virus)*
JE vaccine also should be considered for:
  • Shorter-term travelers (eg, <1 month) with an increased risk for JE based on planned travel duration, season, location, activities, and accommodations[1]
  • Travelers to JE-endemic areas who are uncertain of specific duration of travel, destinations, or activities
JE vaccine is not recommended for:
  • Travelers with very low-risk itineraries, such as shorter-term travel limited to urban areas or travel that occurs outside of a well-defined JE virus transmission season
JE: Japanese encephalitis.
* In general, vaccination is not required for those who work with SA14-14-2 JE vaccine virus only; however, for those working with SA14-14-2 JE vaccine virus at high concentrations or volumes, or passaging virus, individual risk assessments with consideration of biosafety level and vaccination should be undertaken by a local biosafety committee. Vaccination is not required for workers handling routine clinical samples.
Reference:
  1. Hills SL, Walter EB, Atmar RL, et al. Japanese Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep 2019; 68:1.
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