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Comparison of drug interactions with proton pump inhibitors

Comparison of drug interactions with proton pump inhibitors
Concomitant drug Omeprazole Lansoprazole Rabeprazole Pantoprazole Esomeprazole
Warfarin PT decreased by 10 percent - - - -
Diazepam T1/2 increased by 130 percent - - - Decreased clearance
Phenytoin T1/2 increased by 27 percent - - - -
Theophylline - AUC increased by 10 percent - - Unknown
Digoxin AUC increased by 10 percent - AUC, Cmax, T1/2 increased - Unknown
Carbamazepine AUC increased by 75 percent - - - Unknown
PT: prothrombin time; Cmax: maximum plasma concentration; AUC: area under the curve.
Adapted from: Gugler R, Jensen JC, Gastroenterology 1985; 89:1235; Diaz D, Fabre I, Daujat M, et al, Gastroenterology 1990; 99:737; Meyer UA, Eur J Gastroenterol Hepatol 1996; 8(Suppl 1):S21; Parsons ME, Eur J Gastroenterol Hepatol 1996; 8(Suppl 1):S15; Lew EA, Aliment Pharmacol Ther 1999; 13(Suppl 5):11; Lorf T, et al, Eur J Clin Pharmacol 2000; 55:733.
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