| Clinical symptoms and signs | | Fatigue | | Cold intolerance | | Constipation | | Impaired memory | | Slowed mental processing | | Depression | | Nerve entrapment syndromes | | Ataxia | | Muscle weakness | | Muscle cramps | | Menstrual disturbance | | Infertility | | Bradycardia | | Diastolic hypertension | | Hoarseness | | Goiter | | Periorbital edema | | Weight gain | | Galactorrhea | | Laboratory test abnormalities | | Hypercholesterolemia | | Hyponatremia | | Hyperprolactinemia | | Hyperhomocysteinemia | | Anemia | | Creatine phosphokinase elevation | | Radiological abnormalities | | Pericardial and pleural effusions | | Pituitary gland enlargement | | Risk factors for hypothyroidism | | Autoimmune thyroiditis | | Established serological or tissue diagnosis | | Diffuse goiter | | Previous Graves' disease, de Quervain thyroiditis, or painless (postpartum) thyroiditis | | Family history of autoimmune thyroid disease | | Down syndrome | | Turner syndrome | | | Personal or family history of associated autoimmune disorders (eg, vitiligo, pernicious anaemia, adrenal insufficiency, diabetes mellitus type 1, ovarian failure, celiac disease, Sjögren syndrome) | | Primary pulmonary hypertension | | Multiple sclerosis | | Previous thyroid injury | | Thyroidectomy or other neck surgery | | Radioactive iodine therapy | | External radiotherapy | | Exposure to polybrominated and polychlorinated biphenyls, and resorcinol | | Postpartum status | | Drugs impairing thyroid function | | Lithium carbonate | | Amiodarone | | Aminoglutethimide | | Interferon alfa | | Thalidomide | | Betaroxine | | Stavudine | | Hypothalamic disorders | | Hypothalamic or suprasellar mass | | History of hypothalamic radiotherapy or surgery | | Disorders causing hypothalamic dysfunction (eg, sarcoidosis, hemochromatosis, Langerhans cell histiocytosis) | | Pituitary disorders | | Known pituitary tumour | | Other elements of hypopituitarism | | Manifestations of a sellar mass (eg, headache, bitemporal hemianopsia, or diplopia) | | History of pituitary surgery of radiotherapy | | History of head trauma | | History of pituitary apoplexy, including Sheehan syndrome | | History of other disorders causing hypopituitarism (eg, metastatic cancer and lymphocytic hypophysitis) | |
