Light micrograph showing fresh segmental necrotizing lesions with bright red fibrin deposition (arrows). A necrotizing glomerulonephritis can be seen in a variety of inflammatory disorders including vasculitis and lupus nephritis. The latter has prominent immune complex deposition that is generally absent in vasculitis.
Courtesy of Helmut Rennke, MD.
Graphic 53506 Version 2.0
Normal glomerulus
Light micrograph of a normal glomerulus. There are only one or two cells per capillary tuft, the capillary lumens are open, the thickness of the glomerular capillary wall (long arrow) is similar to that of the tubular basement membranes (short arrow), and the mesangial cells and mesangial matrix are located in the central or stalk regions of the tuft (arrows).
