| External beam radiation therapy |
| Previous pelvic irradiation |
| Active inflammatory disease of the rectum |
| Very low bladder capacity |
| Chronic moderate or severe diarrhea from any cause |
| Brachytherapy |
| Previous pelvic irradiation |
| Large-volume gland |
| Marked voiding symptoms |
| Large or high-grade tumor burdens* |
| Chronic moderate or severe diarrhea |
| Active inflammatory disease of the rectum |
| Radical prostatectomy |
| Higher medical operative risk |
| Neurogenic bladder |
| Active surveillance |
| Patients with high prostate cancer anxiety |
| High-grade tumors (>Gleason 6); not stage T1c |
| Prolonged expected survival |
