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Further evaluation of the patient with selective IgM deficiency

Further evaluation of the patient with selective IgM deficiency
Other studies of specific antibody production
Isohemagglutinins (antibody to blood group antigens A and B)
Response to neoantigens (bacteriophage fX174 or keyhole limpet hemocyanin)*
IgG subclass levels
IgG 1, 2, 3, and 4
B and T lymphocyte evaluation
Immunophenotyping of B cells*
CD19+/CD20+/sIgMD+ (immature B cell)
CD19+/CD20+/sIgMD+/sIgDD+ (mature B cell)
CD19+/CD20+/sIgMD+/sIgDD+/CD27+ (memory B cell)
In vitro lymphocyte responses*
B cell proliferation response to SAC
IgM production by B cells in response to SAC and BCDF
Suppressor activity of B cells specific for IgM
IgM: immunoglobulin M; IgG: immunoglobulin G; sIgMD: selective immunoglobulin M deficiency; sIgDD: selective immunoglobulin D deficiency; SAC: Staphylococcus aureus Cowan strain 1; BCDF: B cell differentiation factor.
* May only be available in specialized centers and research laboratories.
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