| Biologic action of VIP | Clinical signs |
| Stimulates secretion and inhibits absorption of sodium, chloride, and water in the bowel | Secretory diarrhea |
| Dehydration | |
| Weight loss | |
| Stimulates potassium secretion in the large bowel | Hypokalemia |
| Inhibits gastric acid secretion | Hypochlorhydria |
| Induces vasodilation | Flushing |
| Stimulates bone resorption | Hypercalcemia |
| Enhances glycogenolysis | Hyperglycemia |
