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Guidelines for pharmacologic intervention in postmenopausal females and males ≥50 years of age

Guidelines for pharmacologic intervention in postmenopausal females and males ≥50 years of age
History of fracture of vertebrae (clinical or subclinical), hip, wrist, pelvis, or humerus.
T-score ≤–2.5 (DXA) at the lumbar spine, femoral neck, or total hip.*
T-score between –1 and –2.5 at the femoral neck or spine, and a 10-year probability of hip fracture ≥3% or a 10-year probability of any major osteoporosis-related fracture ≥20% based upon the United States-adapted WHO algorithm.

DXA: dual-energy x-ray absorptiometry; WHO: World Health Organization.

* Predictive value of isolated measurement of 1/3 radius varies with clinical context.
References:
  1. Watts NB, Adler RA, Bilezikian JP, et al. Osteoporosis in men: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2012; 97:1802.
  2. LeBoff MS, Greenspan SL, Insogna KL, et al. The clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int 2022.
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