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Uptodate Reference Title
Ventilatory response to hypercapnia
Ventilatory response to hypercapnia
Beginning at a normal ventilation of 5 to 8 L/min and a PaCO2 equal to 40 mmHg, ventilation increases linearly as PCO2 rises. In normal individuals there is a range of responsiveness between 2 and 5 L/min/mmHg rise in PCO2. Hypoxemia heightens the response and shifts the curve up and to the left.