| GLP-1 | GIP | |
| Site of synthesis | Small intestinal L cells | Small intestinal K cells |
| Glucose-dependent stimulation of insulin secretion | Yes | Yes |
| Reduction of gastric emptying | Yes | No effect |
| Reduction of inappropriate glucagon secretion | During euglycemia or hypoglycemia: No effect During hyperglycemia: Suppresses glucagon | During euglycemia or hypoglycemia: Stimulates glucagon During hyperglycemia: No effect |
| Weight loss | Yes | Yes |
