| Sulfonylurea | Active, renally-eliminated metabolite |
| Acetohexamide | Hydroxyhexamide, 65 percent |
| Chlorpropamide | Chlorpropamide, 20 percent 2-Hydroxychlorpropamide, 55 percent |
| Tolazamide | Hydroxytolazamide, 35 percent Tolazamide, 7 percent |
| Tolbutamide | Hydroxytolbutamide, 30 percent |
| Glimepiride | Cyclohexylhydroxymethyl derivative, 63 percent |
| Glyburide | 4-hydroxyglyburide, 36 percent |
