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Kinetics of common first generation antipsychotic medications

Kinetics of common first generation antipsychotic medications
Drug Time to peak serum level after oral dosing (hours) Elimination half-life (hours)
Chlorpromazine 3 6 (range: 2 to 119)
Haloperidol -- 10 to 38
Perphenazine -- 8 to 12
Prochlorperazine 2 to 4* 7 to 9
Promethazine -- 7 to 15
Thioridazine -- 21 to 24
Thiothixene 1 to 2 34
Trifluoperazine 2 to 4 24
* Longer if sustained-release formulation is ingested.
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