Stroke with lisinopril versus chlorthalidone in ALLHAT

Increased relative risk of stroke with lisinopril. Graph, with natural logarithmic scale, showing the relative risk of stroke in all studied patients (total) and prespecified subgroups given either lisinopril or chlorthalidone in the ALLHAT study. Compared with chlorthalidone, lisinopril increased the risk of stroke in total and in some specific subgroups.