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Differential splicing of µ and δ mRNA

Differential splicing of µ and δ mRNA
A single primary RNA transcript extending over both mu (µ) and delta (δ) loci, if spliced in the two different ways shown, may generate a mature mRNA encoding the IgM heavy chain or a different one encoding IgD. The IgD hinge region is encoded by a separate exon between Cδ1 and Cδ2 (not shown).
L: light chain gene segment; VH: variable region of heavy chain; D: diversity; JH: joining region of heavy chain; IgM: immunoglobulin M; IgD: immunoglobulin D.
Modified with permission from: Bona C, Bonilla FA. Textbook of Immunology, 2nd ed. Harwood Academic Publishers GmbH, Amsterdam 1996. Copyright © 1996 Overseas Publishers Association, NV. Permission granted by Gordon and Breach Publishers.
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