| NPDR |
| Mild NPDR |
| At least one microaneurysm |
| Criteria not met for other levels of DR |
| Moderate NPDR |
| Hemorrhage/microaneurysm ≥ standard photograph #2A or Soft exudates (cotton wool spots), venous beading, and intraretinal microvascular abnormalities definitely present |
| Criteria not met for severe NPDR, very severe NPDR, or PDR |
| Severe NPDR |
| Hemorrhage/microaneurysm ≥ standard photograph #2A in all 4 quadrants or Venous beading in at least 2 quadrants or Intraretinal microvascular abnormalities ≥ standard photograph #8A in at least 1 quadrant |
| Very severe NPDR |
| Any 2 or more of criteria for severe NPDR |
| Criteria not met for PDR |
| PDR |
| Early PDR |
| New vessels |
| Criteria not met for high-risk PDR |
| High-risk PDR |
| Neovascularization of the disk ≥1/3 to 1/2 disk area or Neovascularization of the disk and vitreous or preretinal hemorrhage or Neovascularization elsewhere ≥1/2 disk area and vitreous or preretinal hemorrhage |
| Severe PDR |
| Posterior fundus obscured by preretinal or vitreous hemorrhage or Center of macula detached |
| CSME |
| Thickening of the retina ≤500 microns from the center of the macula or Hard exudates and adjacent retinal thickening ≤500 microns from macular center or Zone of retinal thickening at least 1 disc area in size located ≤1 disc diameter from the center of the macula |
