American Heart Association (AHA) | European Society of Cardiology (ESC) | British Society for Antimicrobial Therapy (BSAC) | |
Adult dose | Pediatric dose¶ | Adult doseΔ | Adult dose |
Aminoglycoside combination regimen◊ | Aminoglycoside combination regimen | Aminoglycoside combination regimen | |
Aqueous penicillin G 18 to 30 million units per 24 hours IV continuously or in six divided doses for four to six weeks§ or Ampicillin 2 g IV every 4 hours for four to six weeks§ plus Gentamicin¥ 3 mg/kg per 24 hours IV or IM in three divided doses for four to six weeks§ | Aqueous penicillin G 200,000 to 300,000 units/kg per 24 hours IV in six divided doses (maximum dose: 24 million units per 24 hours) for four to six weeks§ or Ampicillin 200 to 300 mg/kg per 24 hours IV divided in four or six divided doses (maximum dose: 12 g per 24 hours) for four to six weeks§ plus Gentamicin¥ 3 to 6 mg/kg per 24 hours IV in two or three divided doses for four to six weeks§ | Amoxicillin 200 mg/kg per 24 hours IV in four or six divided doses for four to six weeks or Ampicillin 12 g per 24 hours (200 mg/kg per 24 hours) IV in four or six divided doses for four to six weeks plus Gentamicin¥ 3 mg/kg per 24 hours IV or IM in one dose for four to six weeks | Amoxicillin 2 g every 4 hours IV for four to six weeks or Penicillin 2.4 g every 4 hours IV for four to six weeks plus Gentamicin¥ 1 mg/kg every 12 hours IV for four to six weeks |
Beta-lactam combination regimen‡† | Beta-lactam combination regimen† | ||
Ceftriaxone 2 g IV every 12 hours for six weeks plus Ampicillin 2 g IV every 4 hours for six weeks | Ceftriaxone 100 mg/kg per 24 hours IV in two divided doses or 80 mg/kg in one daily dose (maximum dose: 4 g per 24 hours; if dose is >2 g per 24 hours, use divided dosing every 12 hours) for six weeks plus Ampicillin (dosing as above) for six weeks | Ceftriaxone 2 g IV every 12 hours for six weeks plus Ampicillin (dosing as above) for six weeks |