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Critical pathways in controlling mycobacterial infection

Critical pathways in controlling mycobacterial infection
Mycobacterial infection induces IL-12 production by monocytes, which stimulates T cells and NK cells to produce IFN-gamma. After binding to its cognate receptor, IFN-gamma activates macrophages to produce TNF-alpha and to kill mycobacteria intracellularly by mechanisms not yet defined. IFN-gamma also drives IL-12 production forward.
IFNγR1: interferon gamma receptor 1; IFNγR2: interferon gamma receptor 2; IL-23R: interleukin 23 receptor; NK: natural killer; IL-12Rβ1: interleukin 12 receptor beta 1; IL-12Rβ2: interleukin 12 receptor beta 2; STAT1: signal transducer and activator of transcription 1; AFB: acid-fast bacilli; TNFαR: tumor necrosis factor alpha receptor; IRF8: interferon regulatory factor 8; GATA2: GATA-binding protein 2; NEMO: nuclear factor kappa B essential modulator.
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