Ophthalmia neonatorum, prophylaxis: Ophthalmic: Instill 1 cm ribbon into each conjunctival sac once.
General dosing, superficial ocular infections: Infants, Children, and Adolescents: Ophthalmic: Instill 1 cm ribbon into affected eye(s) up to 6 times daily depending on the severity of the infection.
Blepharitis: Limited data available: Children and Adolescents: Ophthalmic: Instill ~1 cm ribbon into affected eye(s) 1 or more times daily or at bedtime (AAO [Amescua 2019]).
Conjunctivitis: Infants, Children, and Adolescents: Ophthalmic: Instill ~1 cm ribbon into affected eye(s) 4 times daily for 7 days (Azari 2013).
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
(For additional information see "Erythromycin (ophthalmic): Drug information")
Ocular infections, superficial: Ophthalmic: Instill ~1 cm ribbon into affected eye(s) up to 6 times daily, depending on the severity of the infection.
Blepharitis: Instill ~1 cm ribbon into affected eye(s) one or more times daily or at bedtime (AAO [Amescua 2019]).
Conjunctivitis: Instill ~1 cm ribbon into affected eye(s) 4 times daily for 7 days (Azari 2013).
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Ointment, Ophthalmic:
Generic: 5 mg/g (1 g, 3.5 g)
Yes
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Ointment, Ophthalmic:
Generic: 5 mg/g (1 g, 3.5 g)
For ophthalmic use only. Contact lenses should not be worn during treatment of ophthalmic infections. Avoid contact of tip of ophthalmic ointment tube with affected eye or skin.
Ophthalmia neonatorum prophylaxis: Do not flush ointment from eye following instillation; use a new ointment tube for each neonate.
Avoid contact of tip of ophthalmic ointment tube with affected eye.
Store at 20°C to 25°C (68°F to 77°F); protect from freezing and excessive heat.
Treatment of superficial eye infections involving the conjunctiva or cornea (FDA approved in all ages); prevention of ophthalmia neonatorum due to Neisseria gonorrhoeae or Chlamydia trachomatis (FDA approved in neonates).
Erythromycin may be confused with azithromycin
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not defined.
Ocular: Hypersensitivity, minor ocular irritation, redness
Hypersensitivity to erythromycin or any component of the formulation
Dosage form specific issues:
• For ophthalmic use only. Avoid contamination. Do not touch tip of applicator or let tip of applicator touch eye.
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program
There are no known significant interactions.
Adverse events were not observed in animal reproduction studies. The amount of erythromycin available systemically following ophthalmic application is not known. However, erythromycin ophthalmic is considered acceptable for use in pregnant patients (Robert 2001).
Inhibits RNA-dependent protein synthesis at the chain elongation step; binds to the 50S ribosomal subunit resulting in blockage of transpeptidation
Ointment (Erythromycin Ophthalmic)
5 mg/g (per gram): $8.70 - $12.41
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