ALL/LBL: acute lymphoblastic leukemia/lymphoblastic lymphoma; WBC: white blood cell; Ph: Philadelphia chromsome/t(9;21) rearrangement; LP: lumbar puncture; CNS: central nervous system; IT: intrathecal; MTX: methotrexate; RT: radiation therapy; TLP: traumatic lumbar puncture.
* IT MTX or IT triple therapy, according to the chosen treatment protocol.
ΒΆ The first IT treatment is generally given at the time of the initial diagnostic LP, but it may be delayed for patients with low-risk ALL/LBL with no lymphoblasts in peripheral blood.