Diffuse large B cell lymphoma: Management of second or later relapse in medically-fit patients

This algorithm should be used together with related UpToDate topics for diagnosis, staging, and management of relapsed or refractory DLBCL. Treatment of CNS involvement should be initiated prior to systemic therapy. Refer to related topic for selection of CAR-T cell agent; other options are acceptable where CAR-T cell therapy is not available.