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Causes and risk factors for iron deficiency in adults

Causes and risk factors for iron deficiency in adults
Decreased iron absorption
Celiac disease
Atrophic/autoimmune gastritis
Helicobacter pylori
Bariatric surgery
Medications that reduce gastric acidity (unlikely to be the sole cause)
Genetic disorders such as IRIDA (rare)
Blood or iron loss
Heavy menstrual bleeding
Pregnancy and lactation
Gastric ulcer disease or gastritis
Colorectal cancer
Gastrointestinal telangiectasias, HHT
Bleeding disorders such as VWD
Gastrointestinal parasites
Frequent blood donation
Surgical blood loss
Iatrogenic (frequent blood draws)
Hemodialysis
Evaluation for the underlying cause of iron deficiency is critical. Dietary iron is likely to be sufficient in most adults with access to a varied diet, and iron deficiency should not be ascribed to dietary practices in most adults. High-intensity athletics and urinary or pulmonary hemosiderosis can cause iron deficiency by multifactorial mechanisms. Treatment with an erythropoiesis stimulating agent such as erythropoietin can cause redistribution of body iron stores.
IRIDA: iron refractory iron deficiency anemia; HHT: hereditary hemorrhagic telangiectasia; VWD: von Willebrand disease.
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