Society guideline links: Orthopoxvirus (smallpox and monkeypox)

Introduction — This topic includes links to society and government-sponsored guidelines from selected countries and regions around the world. We will update these links periodically; newer versions of some guidelines may be available on each society's website. Some societies may require users to log in to access their guidelines.

The recommendations in the following guidelines may vary from those that appear in UpToDate topic reviews. Readers who are looking for UpToDate topic reviews should use the UpToDate search box to find the relevant content.

International

●World Health Organization (WHO): Clinical management and infection prevention and control for monkeypox – Interim rapid response guidance (2022)

●WHO: Laboratory testing for the monkeypox virus – Interim guidance (2022)

●WHO: Public health advice for gatherings during the current monkeypox outbreak (2022)

●WHO: Risk communication and community engagement (RCCE) for monkeypox outbreaks – Interim guidance (2022)

●WHO: Surveillance, case investigation and contact tracing for monkeypox – Interim guidance (2022)

●WHO: Vaccines and immunization for monkeypox – Interim guidance (2022)

●WHO: Case definition for notification of smallpox under the IHR (2005) (published 2016)

●WHO: Smallpox – Clinical diagnosis (2016)

Canada

●National Advisory Committee (NACI): Rapid response on interim guidance on the use of Imvamune in the context of monkeypox outbreaks in Canada (2022)

●Public Health Agency of Canada (PHAC): Interim guidance on infection prevention and control for suspect, probable or confirmed monkeypox within healthcare settings (2022)

●PHAC: Monkeypox – Public health management of cases and contacts in Canada (2022)

●PHAC: Canadian Immunization Guide - Smallpox and monkeypox vaccine (2014, updated 2020)

United States

●Advisory Committee on Immunization Practices (ACIP): Use of JYNNEOS (smallpox and monkeypox vaccine, live, nonreplicating) for preexposure vaccination of persons at risk for occupational exposure to orthopoxviruses – Recommendations, United States (2022)

●American Society of Anesthesiologists (ASA)/Anesthesia Patient Safety Foundation (APSF): Statement on monkeypox (2022)

●Centers for Disease Control and Prevention (CDC): Considerations for reducing monkeypox transmission in congregate living settings (2022)

●CDC: Interim clinical considerations for use of JYNNEOS and ACAM2000 vaccines during the 2022 US monkeypox outbreak (2022)

●CDC: Interim guidance for prevention and treatment of monkeypox in persons with HIV infection — United States (2022)

●CDC: Monkeypox – Information for healthcare professionals (2022)

•What healthcare professionals should know

•Case definition

•Clinical guidance

-Clinical recognition

-Considerations for people with HIV

-Pregnancy considerations

-Pediatric considerations

-Monitoring persons exposed

-Isolation and prevention practices

-Clinical treatment

-Pain management

-Tecovirimat

-Obtaining and using TPOXX (tecovirimat)

•Vaccine guidance

•Specimen collection

•Infection control

-Infection control in healthcare settings

-Isolation and infection control at home

-Autopsy and handling of human remains

●CDC: Smallpox – For clinicians (2019)

•Transmission (2016)

•Clinical disease (2016)

•Diagnosis & evaluation (2017)

•Treatment (2021)

•Vaccination information (2017)

●ACIP: Recommendations for the use Vaccinia virus smallpox vaccine in laboratory and health care personnel at risk for occupational exposure to Orthopoxviruses (2015)

Europe

●European Centre for Disease Prevention and Control (ECDC): Considerations for contact tracing during the monkeypox outbreak in Europe (2022)

●ECDC: Interim advice for public health authorities on summer events during the monkeypox outbreak in Europe (2022)

●ECDC: Interim advice on risk communication and community engagement during the monkeypox outbreak in Europe (2022)

●ECDC: Risk assessment – Monkeypox multi-country outbreak (2022)

●ECDC: Risk communication and community engagement approaches during the monkeypox outbreak in Europe (2022)

United Kingdom

●British HIV Association (BHIVA): Rapid statement on monkeypox virus (2022)

●UK Health Security Agency (UKHSA): Monkeypox – Guidance (2022)

•Case definitions

•Contact tracing

•De-isolation and discharge of monkeypox-infected patients

•Diagnostic testing

•Principles for monkeypox control in the UK – 4 nations consensus statement

•Prisons and places of detention

•Cleaning sex-on-premises venues

•Planning events and mass gatherings

•Semen testing for viral DNA

•Vaccination strategy

•Vaccination recommendations

•Reducing risk of transmission at vaccination clinics

●UK Health Security Agency (UKHSA): The Green Book – Smallpox and monkeypox (2013, updated 2022)

●BHIVA: Guidelines on the use of vaccines in HIV-positive adults – Smallpox (2015)

Australia–New Zealand

●Australian Technical Advisory Group on Immunisation (ATAGI): Clinical guidance on vaccination against monkeypox (2022)

●Communicable Diseases Network Australia (CDNA): National guidelines for public health units on monkeypox virus infection (2022)

●Infection Prevention and Control Expert Group (ICEG): Interim guidance on monkeypox for health workers (2022)

●Public Health Laboratory Network (PHLN): Guidance on monkeypox patient referral, specimen collection and test requesting for general practitioners and sexual health physicians (2022)