Your activity: 83 p.v.
your limit has been reached. plz Donate us to allow your ip full access, Email:

Calculator: CNS-IPI (International Prognostic Index for 2-year risk of CNS relapse in DLBCL treated with R-CHOP) in adults

Calculator: CNS-IPI (International Prognostic Index for 2-year risk of CNS relapse in DLBCL treated with R-CHOP) in adults


Kidney and/or adrenal glands involved by lymphoma (1 point)

Age >60 years (1 point)

LDH >normal (1 point)

ECOG performance status (PS) >1* (1 point)

Stage III/IV disease (1 point)

Extranodal involvement >1 (1 point)

Important: Inputs must be complete to perform calculation.

Total criteria point count:


2-year risk of central nervous system relapse of DLBCL treated with R-CHOP

Number of risk factors 2-year risk of CNS relapse
0 0.0%
1 0.8%
2 2.4%
3 4.7%
4 7.4%
5 15.0%
6 32.5%

  • *ECOG performance status (PS) 0 or 1: Fully active or only restricted in strenuous physical activity; no performance restrictions, or fully ambulatory and able to carry out light work.[1]
  • The CNS-IPI was developed using data from >2000 patients (age 18 to 80 years) with aggressive B-cell lymphomas (80 percent DLBCL) treated with rituximab and CHOP-like chemotherapy, who were enrolled in prospective studies and analyzed for occurrence of relapse/progression in the CNS; the resulting risk model was validated with an independent data set of >1500 patients with DLBCL.[2]
  • For information on the use of the CNS-IPI in DLBCL, refer to the UpToDate topic review on Initial treatment of limited-stage DLBCL.
  • CNS: central nervous system; DLBCL: diffuse large B-cell lymphoma; R-CHOP: rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone; ECOG: Eastern Cooperative Oncology Group performance; LDH: lactate dehydrogenase.

Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

Legal Notices and Disclaimer

All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.

EBMcalc is Copyright © 1998-2023 Foundation Internet Services, LLC

Topic 135237 Version 3.0