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Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation classes

Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation classes

CFTR: cystic fibrosis transmembrane conductance regulator; CF: cystic fibrosis; DNA: deoxyribonucleic acid; RNA: ribonucleic acid.
* Elexacaftor appears to function as both a corrector (which works synergistically with tezacaftor) and as a potentiator. The mechanism for the latter is not clear.

Reproduced with permission from: Cystic Fibrosis Foundation. CFTR Mutation Classes. Available at: https://www.cff.org/research-clinical-trials/types-cftr-mutations (Accessed on December 2, 2021). Copyright © 2017 Cystic Fibrosis Foundation.

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