MM: multiple myeloma; BCMA: B cell maturation antigen; Ida-cel: idecabtagene vicleucel; Cilta-cel: ciltacabtagene autoleucel; VDT-PACE: bortezomib, dexamethasone, thalidomide, cisplatin, doxorubicin, cyclophosphamide, and etoposide; DCEP: dexamethasone, cyclophosphamide, etoposide, and cisplatin; DPd: daratumumab, pomalidomide, and dexamethasone; IsaPd: isatuximab, pomalidomide, and dexamethasone; EPd: elotuzumab, pomalidomide, and dexamethasone; KPd: carfilzomib, pomalidomide, and dexamethasone; VPd: bortezomib, pomalidomide, and dexamethasone; VCd: bortezomib, cyclophosphamide, and dexamethasone; DKd: daratumumab, carfilzomib, and dexamethasone; IsaKd: isatuximab, carfilzomib, and dexamethasone; SVd: selinexor, bortezomib, and dexamethasone.
* We use the following cutoffs to define refractory and not refractory MM to guide therapy:ΒΆ When selecting a regimen, avoid agents that the MM is refractory to and prioritize regimens that contain two drugs that the MM has not been exposed to. Options include DPd, IsaPd, EPd, KPd, VPd, VCd, DKd, IsaKd, and SVd.