Age <28 days |
Ill appearance |
Rectal temperature ≥38.6°C (101.5°F; infants 22 to 60 days old only)¶ |
Prematurity (gestational age <37 weeks) |
Received antibiotics within: - Neonates: 7 days of presentation
- Infants 29 to 60 days old: 3 days of presentation
|
Comorbidities or chronic illness (any one of the following): - Perinatal course complicated by surgery or infection
- Medically fragile (technology dependent or require specific therapies to sustain life)Δ
- Documented or suspected immune compromise
- Congenital or chromosomal abnormality
|
Maternal risk for early-onset sepsis (neonates <14 days only, any one of the following): - Peripartum fever
- Prolonged rupture of membranes
- Vaginal culture positive for group B Streptococcus
|
Focal infection◊ |