| CTCAE term | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
| Pruritus | Mild or localized; topical intervention indicated | Widespread and intermittent; skin changes from scratching (eg, edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL | Widespread and constant; limiting self-care ADL or sleep; systemic corticosteroid or immunosuppressive therapy indicated | – | – |
| Definition – A disorder characterized by an intense itching sensation. | |||||
