| Category | Drug class | Weight gain | Alternatives |
| Psychiatric agents | Antipsychotic | Clozapine, risperidone, olanzapine, quetiapine, haloperidol, perphenazine | Ziprasidone, aripiprazole |
| Antidepressants/mood stabilizers: tricyclic antidepressants | Amytriptyline, doxepin, imipramine, nortriptyline, trimipramine, mirtazapine | Bupropion*, nefazodone, fluoxetine (short term), sertraline (<1 year) | |
| Antidepressants/mood stabilizers: SSRIs | Fluoxetine¶, sertraline¶, paroxetine, fluvoxamine | ||
| Antidepressants/mood stabilizers: MAOIs | Phenylzine, tranylcypromine | ||
| Lithium | – | ||
| Neurologic agents | Antiseizure medications | Carbamazepine, gabapentin, valproate | Lamotrigine¶, topiramate*, zonisamide* |
| Endocrinologic agents | Diabetes drugs | Insulin (weight gain differs with type and regimen used), sulfonylureas, thiazolidinediones, sitagliptin¶, metiglinide | Metformin*, acarbose*, miglitol*, pramlintide*, edenatide*, liraglutide* |
| Gynecologic agents | Oral contraceptives | Progestational steroids, hormonal contraceptives containing progestational steroids | Barrier methods, IUDs |
| Endometriosis treatment | Depot leuprolide acetate | Surgical methods | |
| Cardiologic agents | Antihypertensives | alpha-blocker¶, beta-blocker¶ | ACE inhibitors¶, calcium channel blockers¶, angiotensin-2 receptor antagonists |
| Infectious disease agents | Antiretroviral therapy | Protease inhibitors | – |
| General | Steroid hormones | Corticosteroids, progestational steroids | NSAIDs |
| Antihistamines/anticholinergics | Diphenhydramine¶, doxepin¶, cyproheptadine¶ | Decongestants, steroid inhalers |
