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Risk factors and mechanisms for AKI in HCT recipients

Risk factors and mechanisms for AKI in HCT recipients
Intravascular volume depletion
Vomiting and diarrhea associated with acute gut GVHD
Systemic vasodilation
Sepsis
Renal vasoconstriction
Sinusoidal obstruction syndrome
Calcineurin inhibitors
Endothelial injury
Acute GVHD
Calcineurin inhibitors
Total body irradiation
Infection
Transplant-associated thrombotic microangiopathy
Tubular injury
Medications
  • Amphotericin
  • Aminoglycosides
  • Vancomycin
  • Piperacillin-tazobactam
  • Foscarnet
  • Cidofovir
Viruses (adenovirus, BK polyomavirus)
AKI: acute kidney injury; HCT: hematopoietic cell transplant; GVHD: graft-versus-host disease.
From: Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, I, 5th ed, Forman SJ, Negrin RS, Antin JH, Appelbaum FR (Eds), John Wiley & Sons, 2016. Copyright © 2016 John Wiley & Sons Ltd. Reproduced with permission of John Wiley & Sons Inc. This image has been provided by or is owned by Wiley. Further permission is needed before it can be downloaded to PowerPoint, printed, shared or emailed. Please contact Wiley's permissions department either via email: permissions@wiley.com or use the RightsLink service by clicking on the 'Request Permission' link accompanying this article on Wiley Online Library (https://onlinelibrary.wiley.com/).
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