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Uptodate Reference Title
Management of idiopathic hepatic ductopenia in adults
Management of idiopathic hepatic ductopenia in adults
Refer to content on management of idiopathic hepatic ductopenia and vanishing bile duct syndrome.
HAV: hepatitis A virus; HBV: hepatitis B virus. * Cholestasis is defined as alkaline phosphatase ≥2 times the upper limit of normal. ¶ Examples of drugs that are associated with drug-induced liver injury (DILI) include amoxicillin-clavulanate, other penicillins, nonsteroidal antiinflammatory agents, and antifungal agents. Δ Liver biochemical tests include alkaline phosphatase, total bilirubin, alanine aminotransferase, and aspartate aminotransferase. ◊ Ursodeoxycholic acid (UDCA) is initiated at a total daily dose of 13 to 15 mg/kg orally and is usually administered twice daily. § When cholestasis has resolved, UDCA is gradually tapered over two to three months. After UDCA is discontinued, liver biochemical tests are monitored for an additional three to six months. ¥ Refer to UpToDate content on patient selection for liver transplantation.
