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Calculator: Cancer and Aging Research Group-Breast Cancer (CARG-BC) score for older adults


Calculator: Cancer and Aging Research Group-Breast Cancer (CARG-BC) score for older adults

 
Breast cancer stage

II (two) or III (three) (3 points)

I (one) (0 points)
Planned use of anthracyclines

Yes (1 point)

No (0 points)
Planned treatment duration

>3 months (12 weeks) (4 points)

≤3 months (12 weeks) (0 points)
Hemoglobin

≤12 g/dL [≤120 g/L] (female) (3 points)

≤13 g/dL [≤130 g/L] (male) (3 points)

>12 g/dL [>120 g/L] (female) (0 points)

>13 g/dL [>130 g/L] (male) (0 points)
Liver function

Abnormal LFTs, outside reference ranges (3 points)

Normal, within reference ranges (0 points)
Falls in past 6 months

≥1 (4 points)

0 (zero) (0 points)
Limited in walking more than a mile

Somewhat or very limited (3 points)

Not limited at all (0 points)
Availability of support (someone to give good advice in a crisis)

None, little, or some of the time (3 points)

Most or all of the time (0 points)

 
Important: Inputs must be complete to perform calculation.

 
Total criteria point count:
 

 

CARG-BC score interpretation

 
0 to 5 points: 27% risk of Grade 3 to 5 toxicities
6 to 11 points: 45% risk of Grade 3 to 5 toxicities
12 to 24 points: 76% risk of Grade 3 to 5 toxicities

 
Notes
  • The CARG-BC score was developed to predict toxicity from chemotherapy specifically in older adults with early breast cancer, with better prediction than either the Karnofsky Performance Status (KPS) or the more general CARG in this subset. It was developed using data prospectively collected from 473 patients age ≥65 years with stage I to III breast cancer from 16 institutions, treated with neoadjuvant or adjuvant chemotherapy.
  • Chemotherapy-related toxicities: Grade 3 = severe; Grade 4 = life-threatening; Grade 5 = fatal.
  • LFTs: liver function tests.

 
Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

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