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Collagen IV network

Collagen IV network
In panel A, protomers create basement-membrane networks with other protomers by uniting two NC1 trimers to form an interface hexamer (Panel B) at the C-terminal and by uniting four triple helical 7s domains at the N-terminal.
From: Hudson, BG, Tryggvason, K, Sundramoorthy, M, Neilson, EG. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N Engl J Med 2003; 348:2543. Copyright © 2003 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
Graphic 130689 Version 1.0