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Prothrombotic risk factors for BCS

Prothrombotic risk factors for BCS
  1. Acquired thrombophilia
  • Myeloproliferative disease
  • Polycythemia vera
  • Essential thrombocytosis
  • Idiopathic myelofibrosis
  • JAK2 V617F mutation
  • Paroxysmal nocturnal hemoglobinuria
  • Behçet disease
  • Hyperhomocysteinemia
  • Antiphospholipid syndrome
  1. Inherited thrombophilia
  • Factor V Leiden
  • Prothrombin gene G20210A mutation
  • MTHFR C677T mutation
  • Thalassemia
  • PC deficiency
  • Protein S deficiency
  • Antithrombin deficiency
  1. Systemic factors
  • Sarcoidosis
  • Vasculitis
  • Behçet disease
  • Connective tissue disease
  • Inflammatory bowel disease
  1. Hormonal factors
  • Recent oral contraceptive use
  • Pregnancy
BCS: Budd-Chiari syndrome; JAK2: janus kinase 2; MTHFR: methyltetrahydrofolate; PC: protein C.
From: Simonetto DA, Singal AK, Garcia-Tsao G, et et al. ACG Clinical guideline: Disorders of the hepatic and mesenteric circulation. Am J Gastroenterol 2020; 115:18. DOI: 10.14309/ajg.0000000000000486. Copyright © 2020 The American College of Gastroenterology. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.
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