Pretreatment magnetic resonance axial T2-weighted FLAIR image (A) demonstrates a normal appearance of the cortex and hypointense white matter. Following CAR-T cell infusion and neurologic deterioration, repeat imaging (B) demonstrates diffuse cortical thickening (arrow) and hyperintensity in the white matter (asterisk) reflective of edema.
From: Guha-Thakurta N, Wierda WG. Cerebral edema secondary to chimeric antigen receptor T-cell immunotherapy. Neurology 2018; 91:843. DOI:
10.1212/WNL.0000000000006436. Copyright © 2018 American Academy of Neurology. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.
